Follistatin 344
Follistatin 344 is a peptide variant derived from the follistatin protein and is commonly studied for its interaction with myostatin and activin-related signaling pathways involved in cellular growth regulation.
This peptide is for research purposes only. Not for human consumption.
Description
Myostatin and Activin Binding
Follistatin is known for its high-affinity binding to members of the TGF-β superfamily, including myostatin and activins [1]. Research models use Follistatin 344 to examine how inhibiting these ligands alters downstream signaling cascades associated with cell growth, differentiation, and tissue modeling. These studies often focus on pathway inhibition mechanics rather than endpoint outcomes.
Growth Regulation Signaling
By neutralizing myostatin activity in experimental systems, Follistatin 344 is used to explore regulatory mechanisms that control cellular growth balance [2]. Researchers assess transcriptional markers, receptor activity, and intracellular signaling changes under controlled conditions to better understand growth-related signaling networks.
Peptide Structure and Research Use
The 344-amino-acid form is frequently referenced in studies examining isoform-specific activity and stability. Its defined sequence allows consistent inclusion in comparative signaling and pathway inhibition studies [1].
Key Specs
- Peptide class: Follistatin isoform
- Research context: myostatin and activin pathway signaling
- References: PubChem and PubMed [1,2]
Referenced Citations
- PubChem, Follistatin: https://pubchem.ncbi.nlm.nih.gov/compound/Follistatin
- PubMed, Myostatin and follistatin signaling: https://pubmed.ncbi.nlm.nih.gov/15240824/
Myostatin and Activin Binding
Follistatin is known for its high-affinity binding to members of the TGF-β superfamily, including myostatin and activins [1]. Research models use Follistatin 344 to examine how inhibiting these ligands alters downstream signaling cascades associated with cell growth, differentiation, and tissue modeling. These studies often focus on pathway inhibition mechanics rather than endpoint outcomes.
Growth Regulation Signaling
By neutralizing myostatin activity in experimental systems, Follistatin 344 is used to explore regulatory mechanisms that control cellular growth balance [2]. Researchers assess transcriptional markers, receptor activity, and intracellular signaling changes under controlled conditions to better understand growth-related signaling networks.
Peptide Structure and Research Use
The 344-amino-acid form is frequently referenced in studies examining isoform-specific activity and stability. Its defined sequence allows consistent inclusion in comparative signaling and pathway inhibition studies [1].
Key Specs
- Peptide class: Follistatin isoform
- Research context: myostatin and activin pathway signaling
- References: PubChem and PubMed [1,2]
Referenced Citations
- PubChem, Follistatin: https://pubchem.ncbi.nlm.nih.gov/compound/Follistatin
- PubMed, Myostatin and follistatin signaling: https://pubmed.ncbi.nlm.nih.gov/15240824/
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