FOX04-DRI (Proxofim)
FOXO4-DRI is a synthetic peptide designed to disrupt FOXO4-p53 interactions and is studied in cellular senescence and aging pathway research models.
This peptide is for research purposes only. Not for human consumption.
Description
FOXO4-p53 Interaction Research
FOXO4-DRI was developed to selectively interfere with the binding between FOXO4 and p53, a pathway associated with senescent cell survival [1]. Research models investigate how this disruption influences senescence-associated signaling and transcriptional regulation.
Cellular Senescence Models
Studies involving FOXO4-DRI examine senescent cell markers, apoptosis-related signaling, and stress-response pathways [2]. These investigations contribute to broader research into aging-associated cellular mechanisms.
Molecular Design and Specificity
The D-retro-inverso (DRI) design improves peptide stability and resistance to degradation, making it suitable for controlled pathway analysis [1].
Key Specs
- Peptide class: DRI-modified signaling peptide
- Research context: senescence, FOXO4-p53 signaling
- References: PubMed [1,2]
Referenced Citations
- PubMed, FOXO4-DRI and senescent cells: https://pubmed.ncbi.nlm.nih.gov/28671688/
- PubMed, FOXO4 in aging research: https://pubmed.ncbi.nlm.nih.gov/29559565/
FOXO4-p53 Interaction Research
FOXO4-DRI was developed to selectively interfere with the binding between FOXO4 and p53, a pathway associated with senescent cell survival [1]. Research models investigate how this disruption influences senescence-associated signaling and transcriptional regulation.
Cellular Senescence Models
Studies involving FOXO4-DRI examine senescent cell markers, apoptosis-related signaling, and stress-response pathways [2]. These investigations contribute to broader research into aging-associated cellular mechanisms.
Molecular Design and Specificity
The D-retro-inverso (DRI) design improves peptide stability and resistance to degradation, making it suitable for controlled pathway analysis [1].
Key Specs
- Peptide class: DRI-modified signaling peptide
- Research context: senescence, FOXO4-p53 signaling
- References: PubMed [1,2]
Referenced Citations
- PubMed, FOXO4-DRI and senescent cells: https://pubmed.ncbi.nlm.nih.gov/28671688/
- PubMed, FOXO4 in aging research: https://pubmed.ncbi.nlm.nih.gov/29559565/
Reviews
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